Ras 同源基因-Rho相關(guān)螺旋卷曲蛋白激酶(Ras homolog gene/a Rho-associated coiled coil-forming protein kinase,Rho-ROCK)信號(hào)途徑是中樞神經(jīng)系統(tǒng)中普遍存在的一條通路,是介導(dǎo)抑制性信號(hào)阻斷中樞神經(jīng)細(xì)胞再生的重要途徑。
Y-27632: (1R,4r)-4-((R)-1-aminoethyl)-N-(pyridine-4-yl) cyclohexane-carboxamid-2HCl, is a Rho-associated kinase (ROCK) inhibitor. Y-27632 has been shown to prevent apoptosis as well as enhance the survival and cloning efficiency of dissociated human embryonic stem (ES) cells without affecting their pluripotency.
Purity: Greater than 99% as determined by LC/MS analysis. LC/MS and/or NMR data available upon request.
Biological Activity: Tested active for culturing human iPS cells in serum-free medium on Matrigel coated plates.